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"The Driver" is specialist in a rare business: he drives getaway cars in robberies. His exceptional talent prevented him from being caught yet. After another succeeded flight from the police, a self-assured detective makes it his primary goal to catch the Driver. He promises remission of of punishment to a gang if they help to convict him in a set-up robbery. The Driver seeks help from the player Isabelle to mislead the detective.

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As panic spreads, the governor of Virginia quarantines neighborhoods where cases have cropped up, and federal officials confess they have no vaccine and scant supplies of antiviral drugs. Major socioeconomic disruption sets in, with shortages of food

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In New York, the competent creative director of Birk Advertising Eddie Shneider is living a successful moment of his professional life and is engaged and has just proposed Judy Birk, the daughter of the owner of the company where he works. Eddie is also a wolf and very successful with many women, and is having an affair with a neighbor of the street where he lives with Judy. When he gets the account of the greatest American airline for his company, he is promoted to partner and he celebrates with his assistant and friend Angelina Sable in a lunch party in a restaurant. After hours, when they are in the garage, Angeline notes that she had forgotten her car keys in the office, and when she returns, she is violently raped by the despicable brother of Judy, Anthony Birk. On the next morning, when Eddie arrives in the garage, he finds the traumatized Angeline on the floor and he takes her to a hospital. He returns to the company and Anthony blackmails Eddie with pictures of his many affairs. Eddie has to take a side between his career and engagement and his friendship with Angeline.